Endoderm is one of the three germ layers and possesses potential to differentiate into organs such as liver, pancreas and lung. Celther Polska has developed unique protocols to obtain definitive endoderm from pluripotent stem cells. The endoderm cells can be used for differentiation into hepatocytes, insulin producing cells, thyroid cells and others. The endodermal cells are also utilized in cytotoxicity testing of small molecules.

In order to evaluate the results of differentiation, Celther Polska endodermal cells are tested for the presence of characteristic endoderm markers: FOXA2 and CXCR4.