Trisomy 18, also called Edwards syndrome, is a chromosomal condition associated with abnormalities in many parts of the body. Individuals with trisomy 18 often have slow growth before birth (intrauterine growth retardation) and a low birth weight. Affected individuals may have heart defects and abnormalities of other organs that develop before birth. Other features of trisomy 18 include a small, abnormally shaped head; a small jaw and mouth; and clenched fists with overlapping fingers.

Key hallmarks of iPSc with chromosome 18 trisomy

•   Generated from cells from patients with Edwards Syndrome
•   Expressed pluripotent genes
•   Exhibited normal proliferation

Molecular markers

TRA1-60 and TRA1-80

Study human 18 trisomy