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IN VITRO TOXICITY TESTING
Drug toxicity is a key reason for drug candidate rejection. Identifying potential toxicity at an early stage in drug discovery can save both time and developmental costs, and most importantly reduce the likelihood of late stage failure.
Advantages of in vitro toxicity testing:
Advantages of in vitro toxicity testing:
- Provides useful information to clarify toxicity generation and its mechanism
- High throughput allows for direct comparison of multiple compounds tested under the same
conditions - Allows for potential optimization of the concentration ranges in regard to the toxic doses
- Effects of tested compounds on proliferation or survival rates can be tested, along with their kinetics
- Time - saving: eliminates toxicological compounds in the early phase of drug discovery process
IN VITRO TOXICITY TESTING PROVIDED BY CELTHER:
Hepatotoxicity testing
Hepatotoxicity is the leading cause of drug withdrawals in late-stage drug development (about approximately 30% of all drug withdrawals).
In order to avoid the potential hepatotoxic effects of lead compounds, Celther Polska developed fast and accurate hepatotoxicity tests using induced hepatocytes, derived from iPS cells. This highly relevant model is optimized for high-throughput screening.
In order to avoid the potential hepatotoxic effects of lead compounds, Celther Polska developed fast and accurate hepatotoxicity tests using induced hepatocytes, derived from iPS cells. This highly relevant model is optimized for high-throughput screening.
Neurotoxicity testing
Neuronal tissue is composed of highly sensitive cells that can be easily damaged by cytotoxic agents. It is therefore vital that all drug candidates are tested for neurotoxicity.
To enable testing of compounds with potential therapeutic activity, Celther Polska has developed neurotoxicity tests based on induced neural stem cells, derived from iPS cells. Such tests can be streamlined and carried out in a high-throughput fashion, therefore eliminating the toxic compounds at the early stages of drug development.
To enable testing of compounds with potential therapeutic activity, Celther Polska has developed neurotoxicity tests based on induced neural stem cells, derived from iPS cells. Such tests can be streamlined and carried out in a high-throughput fashion, therefore eliminating the toxic compounds at the early stages of drug development.
Cardiotoxicity testing
Celther Polska has started to offer in vitro cardiotoxicity testing based on induced human cardiomyocytes derived from iPS cells. These cells are specifically designed to support drug discovery and improve the predictability of drug efficacy and toxicity screens, weeding out ineffective and potentially toxic compounds at early stage of drug development before significant time and resources have been invested.
Cytotoxicity testing on human primary cancer cells
Celther Polska designs and performs in vitro safety testing programs for the biologics, pharmaceutical, biopharmaceutical, medical device, chemical, agrochemical, cosmetic and food industries.
We offer conducting cytotoxicity tests of different compounds, both on BALB cell line and Human primary cancer cell lines, which allow to evaluate the biological response to a material intended for use.
We prepare customized offer for each client. For more information please contact our order center .
Cytotoxicity testing on human primary cancer cells
Celther Polska designs and performs in vitro safety testing programs for the biologics, pharmaceutical, biopharmaceutical, medical device, chemical, agrochemical, cosmetic and food industries.
We offer conducting cytotoxicity tests of different compounds, both on BALB cell line and Human primary cancer cell lines, which allow to evaluate the biological response to a material intended for use.
We prepare customized offer for each client. For more information please contact our order center .
Exemplary toxicology tests:
- Apoptosis and necrosis
- Senescence
- Cytostatic effect
- Influence on differentiation
- Cell observation in real-time
Download brochure about in vitro toxicity testing services provided by Celther